Annihilate is a fat-burning supplement by BPM Labs.

It aims to improve body composition by increasing metabolic rate and fat oxidation.

BPM Labs is an American-based supplement company with part UK and Australian ownership.

Ingredients Label

Active Ingredients

African Mango

Irvingia Gabonensis is a supplement extracted from the seeds of a plant called African Mango.

Studies have shown that supplementing with African Mango contributes to weight loss (1). Looking deeper though, it look like this is due to blunting hunger rather than direct fat-burning effects.

150mg of extract appears to be an effective dose for blunting hunger.

Green Tea Extract

Green Tea and its extracts have long been used for fat-burning effects.

Studies show that it can increases fat oxidation by 17% compared to placebo (2), as well as improving insulin sensitivity.

An effective dose for fat-burning is 400-500mg.

Cacao Plant Extract

Cacao Plant Extract has been shown to significantly increase blood flow, which may lead to improved rates of recovery and improving workouts (3).

Fat-burning benefits, however, has little supporting evidence.

The standard dose is 500–1,000mg a day, taken with meals.

Naringin

Naringin is a flavonoid extracted from the inner peel of grapefruit and some other citrus fruits. It hinders the regulation of the metabolism of some medications and supplements, allowing more of other ingredients to be absorbed than usual (4).

It is believed to enhance the fat-burning effects of caffeine and some other compounds.

An optimal dose has not yet been established.

Tetradium Extract

Tetradium is a type of plant grown in East-Asia.

Its extract has been shown to have thermogenic and stimulatory effects, and animal studies have shown reductions in fat gain with supplementation (5).

Human studies are needed, and an optimal dose has not been established.

Bitter Orange Peel Extract

Bitter Orange is a pomelo/mandarin hybrid, whose extract is used to aid weight-loss and suppress appetite.

Studies have shown it to increase resting metabolic rate and energy expenditure. Results were best seen over 6-12 weeks of supplementation (6).

Taurine

Taurine is an amino acid often used in pre-workout formulas for its cell-volumising properties, however it can also come in handy for fat loss.

It was shown by one study to increase fat oxidation by 17% in well-trained athletes (7).

An effective dose is about 1g daily.

Caffeine

Caffeine is widely used for its mental and physical stimulant effects, which increase alertness and power output.

It is also beneficial for fat loss via increases in metabolic rate (8) and fat oxidation (9).

An effective dose for fat-burning can be as low as 200mg, but higher doses might be needed for those with greater tolerance.

Nandina Domestica Extract

Nandina Domestica is a fruit-tree containing a compound called Higenamine.

This compound has been reported to have similar effects to Ephedrine, which has fat-burning properties. But Higenamine may be a better alternative as Ephedrine is currently highly regulated in Australia and NZ.

Studies still need to be done in humans, however an effective dose may be 20-30mg taken 2-3 times daily.

Eria Jarensis Extract

Eria Jarensis is a plant in the Orchid family.

Its extract contains a compound called N-Phenyldimethylamine, that may have similar effects to PEA (mood-booster) and DMAA (banned amphetamine derivative).

This substance is new and very under-researched, and may be quite strong. Caution should be exercised as it could be dangerous, especially when paired with other stimulants.

Who Takes It?

BPM Labs Annihilate is geared toward anyone wishing to improve their fat-loss, mood, and workout effectiveness while dieting.

How To Take

Begin by taking a half-scoop with 150-200mL of water. Stir sufficiently and consume on an empty stomach to assess tolerance.

Standard serving: Add 1 scoop to 350-500ml of water, and consume on an empty stomach.

Do not take within 5 hours of sleeping, or use any more than 2 scoop in a 24-hour time period.

Side Effects

Bitter orange may have serious drug interactions in a similar way to grapefruit.

Eria Jarensis Extract may increase blood pressure significantly, in a similar fashion to the now-banned substance DMAA.

Many of the less-researched ingredients may have unknown side effects. Stop supplementation immediately if you experience anything unusual.

Pros

• Proven ingredients like Green Tea Extract, Caffeine, and Taurine are included
• New and promising ingredients have also been used, in true BPM Labs fashion

Cons

• The less-researched ingredients could be ineffective or even dangerous, particularly Eria Jarensis Extract
• Since this is a proprietary blend, we do not know how much of each ingredient is in a serving

Conclusion

BPM Labs are once again thinking outside the box with Annihilate, stacking tried-and-tested ingredients with some exciting new ingredients.

Whether they all work in the long run remains to be seen.

We recommend you try this supplement with caution, starting with a low dosage, and stopping immediately if there are any adverse side effects.

For a full list of the fat burner ingredients shown to work, click here.